The Presence of Mef (E) and Erm (B) Genes in Throat Samples of Children Infected with Streptococcus pyogenes

Aim: Antibiotic resistance studies about the Streptococcus have a great importance for treatment of especially child throat infections in terms public health and rational antibiotic use. For this purpose, we aimed to identify macrolide genes mef(E) erm(B). Material Method: The culture samples taken from 51 children presenting hospital with complaint sore were evaluated laboratory, S. pyogenes was diagnosed using tests; gram staining, catalase, bacitracin PYR. Susceptibility profile determined Kirby-Bauer disk-diffusion method minimum inhibitor concentration(MICs) erythromycin clindamycin by VITEK 2 System. Results: possible erm(B) PCR. Macrolide are pateients as follows; benzylpenicillin 0%, erytromycin 74.5%, 31.4%. In patients pyogenes, genetic determinants investigated PCR primers specific each gene. Total 48% isolates (n=24) positive erm (B), 10% (n=5) mef(E), 42% (n=21) both detected. Conclusion: results our study show that macrolid found five evaluated. When anamnesis these examined, it there frequently presented experienced re-infection within few weeks after receiving treatment.